Resistance Training Improves Strength, Motor Function of Children with CP, Analysis Concludes

Resistance Training Improves Strength, Motor Function of Children with CP, Analysis Concludes

Resistance training exercises can improve muscle strength and motor skills in children with cerebral palsy (CP), according to a recent review study.

More studies, however, are necessary to understand the clinical relevance of the results and find the best training regimens, researchers noted.

The study, “Impact of Resistance Therapy on Motor Function in Children with Cerebral Palsy: A Systematic Review and Meta-Analysis,” was published in the International Journal of Environmental Research and Public Health.

Current evidence suggests that muscle weakness associated with CP may contribute to disability to a greater extent than spasticity (muscle stiffness), which is one of the most common problems for those with a neurological disease.

In the past, clinicians thought that using resistance training, also known as strength training, to improve patients’ motor function could aggravate spasticity. Resistance training is a type of physical exercise that induces muscular contraction and builds muscle strength, endurance and mass.

However, recent studies have contradicted this hypothesis, suggesting that resistance exercises could increase muscle strength without increasing spasticity. Subsequent investigations also have found that resistance therapy could improve muscle strength in children with cerebral palsy with benefits in gait and motor function.
However, so far, data on the impact of this type of training on motor function has been inconclusive.
Now, researchers undertook a review of literature and conducted an analysis of studies (a meta-analysis) to evaluate the impact of resistance therapy on motor function in children with CP.
They searched for published clinical trials that evaluated the effects of resistance training in school-age children with CP.
A total of 15 studies were evaluated: 12 controlled clinical trials that compared children who received resistance training versus a control group that received conventional therapy or no intervention, and three non-controlled clinical trials that evaluated a single group of children who received resistance training.

Overall, 384 children were included in the studies. These children varied in their gross motor skills: from patients who were able to walk and climb independently up to children who had some difficulty walking and balancing and needed some assistance for mobility (railing, hand-held device or wheelchair for longer distances).

The training programs tested varied between trials, ranging from progressive strength training (constantly increased to facilitate adaptation), a table of resistance exercises, functional training (performing work against resistance), and exercises on a static bicycle.

Motor effects were assessed using tests to measure gross motor functions, including lying, sitting, crawling and kneeling, standing, walking, running and jumping, as well as balance and strength. Tests included the Gross Motor Function Measure (GMFM), Lateral Step Up (LSU), Timed Up and Go (TUG), and Mobility Questionnaire (MobQue).

The pooled analysis favored the use of resistance therapy to improve muscle strength in children with CP. Moreover, it pointed to strength training as a way not only to reduce muscle weakness, but also improve children’s physical capacities and mobility.

It also suggested a larger benefit when the therapy duration was less than or equal to six weeks, when sessions took fewer than three days a week, and when the duration of each session was less than 30 minutes.

However, researchers warn that the benefits measured may be overestimated due to publication bias, meaning a greater tendency to publish trials that demonstrate a positive effect, in contrast to those that show no — or negative — effects.

“All future randomized controlled clinical trials should be registered and published to address this issue. Future studies should also analyze the clinical relevance of the results, examining the most optimal regimens in terms of duration of therapy, number of sessions, duration of each session, and type of intervention protocol used,” the researchers concluded.

Ana is a molecular biologist with a passion for discovery and communication. As a science writer she looks for connecting the public, in particular patient and healthcare communities, with clear and quality information about the latest medical advances. Ana holds a PhD in Biomedical Sciences from the University of Lisbon, Portugal, where she specialized in genetics, molecular biology, and infectious diseases.
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Ana holds a PhD in Immunology from the University of Lisbon and worked as a postdoctoral researcher at Instituto de Medicina Molecular (iMM) in Lisbon, Portugal. She graduated with a BSc in Genetics from the University of Newcastle and received a Masters in Biomolecular Archaeology from the University of Manchester, England. After leaving the lab to pursue a career in Science Communication, she served as the Director of Science Communication at iMM.
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Ana is a molecular biologist with a passion for discovery and communication. As a science writer she looks for connecting the public, in particular patient and healthcare communities, with clear and quality information about the latest medical advances. Ana holds a PhD in Biomedical Sciences from the University of Lisbon, Portugal, where she specialized in genetics, molecular biology, and infectious diseases.
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